Prof. Bass Hassan

• Professor of Medical Oncology, Oxford Institute for Molecular Pathology, Sir William Dunn School of Pathology. Fellow of Lincoln College, University of Oxford.
• Head of the Sarcoma and Teenage and Young Adult Oncology Unit and Consultant Medical Oncologist, Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospital NHS Foundation Trust.

His research interests address interactions between the growth promoting function of the ligand, insulin-like growth factor 2, and its non-signalling IGF2 receptor. Genetic models of the IGF system have established the key role of this signalling pathway in tumour growth control. This provides an excellent basis to study how tumour progression is orchestrated in vivo, from pre-malignant changes to established tumours, and how this information can be translated to human cancer prevention, diagnosis and treatment. Current projects include: Structure and function of the IGF2 receptor; functional genetics of Igf2 and Igf2r and tumour growth control; development of soluble human IGF2 receptor as an IGF2 ligand trap and structure and function of the RE-1 silencing repressor transcription complex.